Andy Griffith is an American actor. He starred in Grampa's favorite show, Matlock.
During a public appearance Abe and Jasper swiped Matlock's pills, which were needed to prevent him from having a spastic heart failure.
The Simpson family watched Before They Were Famous when Shary Bobbins was their nanny. When they watched the show Homer asked Shary to get him a beer. The episode they watched showed Rainier Wolfcastle's first appearance in a commercial and Charles Bronson as Andy Griffith in The Andy Griffith Show.
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When reflecting the 20th century, Grampa lamented that it was terribly boring and full of unruly teenagers, but then decided it was alright because "we did have two shows with Andy Griffith".