- "[...] Springfield's unending nightmare, the Simpsons."
- ―Mayor Quimby, describing how the Simpsons affected Springfield.[src]
The Simpson family is one of the main families in Springfield, as well as the protagonist family of The Simpsons. The first known Simpson was Sven. Many families married in to the Simpson family and the Simpsons, in turn, married into many. Through marriages such as this, it is possible to trace a link between one of the state's richest and well-known family, the Burns family.
The first known Simpson was Sven. He married Claretta Elthridge and had two children. One of them, Rupert, married Winifred Running Goat, a Native American. They had five children, which included Trixie and Garwood. Trixie married Gaylord Stemple, and they had three children. Garwood married Clowta Stillman, and they had four children. Howland married Gabby Crouse, and they had five children: Lou, Dulcine, Hugo, Gaston, and Old Tut Simpson. Lou married Zorina Ovadia, and they had three children: Eckhardt, Bob and Twyla. Twyla married Woody Schedeen and had two daughters Fernice and Ingrid. Eckhardt married Griselda Johnson and had four children: Verna, Vern, Eckhardt, and Lotus.
Old Tut Simpson married "Happy" Dinsdale, and they had four children, including Orville. Orville married Yuma Hickman. They had Abraham Simpson and his brothers. They moved back to the US, and Abraham met Mona. They had Homer, who married Marge Bouvier and had Bart, Lisa, and Maggie. Abe also had an affair with an unknown cRNY woman, which resulted in Herb, adopted by the Powell family, and a short affair with Edwina during WWII, which resulted in Abbey.
Relatives with an unknown/unclear position in the family tree
- 'Sueing' relative
- Boris Simpson – Homer's great-uncle
- Dr. Simpson
- Francine Simpson - Homer's cousin
- Hortense Simpson – Bart or Homer's aunt or great-aunt.
- Hurt leg relative
- Jug band manager
- Millionaire actor
- Virgil Simpson – (Possibly Homer's great-great-great grandfather)
- Mabel Simpson - Homer's great-great-great grandmother. Possibly the same person as Clowta Stillman.
- Hiram Simpson - Mabel's ex-husband and Eliza Simpson's father. Possibly the same person as Garwood Simpson. May or may not be related to the Simpsons, depending on Abe's story about Virgil's accuracy.
- Abraham Simpson I – Homer's great-great grandfather and allegedly Virgil and Mabel's son. Possibly the same person as Howland Simpson.
- Eliza Simpson – Hiram Simpson's daughter, Milford Van Houten's wife and Milhouse Van Houten's great-great-great-great-great-grandmother.
- Bart-Beard the Pirate – Distant ancestor of the Simpsons. May or may not be related to the Simpsons, depending on the accuracy of Abe's story about Virgil.
- Prison snitch relative
- Abigail Simpson
- Fester Simpson – Uncle of either Homer or his children.
- Jessica Simpson – Cousin of either Homer or his children.
- Valerie Togasaki – Cousin of either Homer or his children.
- Cathy – Cousin of either Homer or his children.
- Beggar relative
- Homer – A thief who lived in 1200 B.C. and ancestor of Homer Simpson.
- Hugo Simpson – Bart's twin brother
- Maggie Simpson, Jr. – Maggie's future daughter
- Cyrus Simpson – Grampa's older brother
- Jim Simpson – A boxer
- Zia Simpson – Lisa's future daughter
- Milhouse Van Houten – Lisa's future husband
- Kang – Maggie's "real" father
- Skippy Simpson – Bart Simpson's future son
- Jiff Simpson – Bart Simpson's future son
- Homer Simpson– According to Abe, he is Homer Simpson's great-great-great-grandfather.