• Wikisimpsons needs more Featured Article, Picture, Quote, Episode and Comprehensive article nominations!
  • Wikisimpsons has a Discord server! Click here for your invite! Join to talk about the wiki, Simpsons and Tapped Out news, or just to talk to other users.
  • Make an account! It's easy, free, and your work on the wiki can be attributed to you.

Madame Eczema

Wikisimpsons - The Simpsons Wiki
Radioactive Man Icon.png The contents of this article or section are related to the Radioactive Man universe. They are considered fictional in The Simpsons.
Madame Eczema
Madame Ecezema.png
Supervillain Information
Female ♀
Hair: Purple
Occupation: Leader of Eczema
First appearance: The Heroic Life and Mortifying Death of Radioactive Man: Chapter I

Madame Eczema is a supervillain and the leader of Eczema.


Madame Eczema used to be a pretty girl until she started to get eczema, seborrhea and psoriasis on her face. This affected one side of her face, so she used her hair to cover it and took up a life of crime. She eventually fired her dermatologist and joined Eczema, working her way up the ranks by killing off her superiors.[1]

Madame Eczema revealed to the world that Radioactive Man was Claude Kane III.[2] After Radioactive Man's supposed death, Madame Eczema pretended to be Plasmo and called the Superior Squad to Crystal Belle's Crystal Balls.[1] The plan worked and she managed to knock out and capture the Superior Squad.[3] However, Radioactive Man, who turned out to still be alive, found them and rescued them. Gloria Grand then knocked out Madame Eczema.[4]