Eczema are a secret evil society led by Madame Eczema.
When Madame Eczema joined Eczema, she worked her way to the top by killing her superiors.
Radioactive Man fought against Eczema and the leader, Madame Eczema, revealed to the world that Radioactive Man was Claude Kane III. Radioactive Man was then killed by Eczematous-Prime. It later turned out that Radioactive Man faked his death so that he could keep his identity safe.
Madame Eczema used Eczema to hold a fake seance so she could capture the Superior Squad. The plan worked and Madame Eczema planned to kill the Superior Squad live on TV. However, Radioactive Man came in and rescued the Superior Squad, who took down Eczema.
Black Partridge was seen fighting against Eczema as Sheldon Phillips walked by them.