Picture
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Name
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Role in Seinfeld
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Role on The Simpsons
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Jason Alexander
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Played George Costanza.
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Voiced Bourbon Verlander in "The Caper Chase".
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Michael Chiklis
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Played Steve in "The Stranded".
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Voiced the handsome quarterback in the season 28 episode "The Town".
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Bryan Cranston
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Played Tim Whatley in "The Mom and Pop Store", "The Label Maker", "The Jimmy", "The Yada Yada", and "The Strike".
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Voiced Stradivarius Cain in "The Spy Who Learned Me".
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Janeane Garofalo
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Played Jeannie Steinman in "The Invitations" and "The Foundation".
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Voiced herself in "The Last Temptation of Krust" and "The Ten-Per-Cent Solution".
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Brian George
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Played Baby Bhatt in "The Cafe", "The Visa" and "The Finale".
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Voiced several British men in "The 7 Beer Itch" and "The Man from G.R.A.M.P.A.".
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Kathie Lee Gifford
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Played herself in "The Opposite".
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Voiced herself in the season 10 episode "Treehouse of Horror IX", via live-action recording.
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Dana Gould
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Played Frankie Merman in "The Junk Mail".
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Worked as a co-executive producer and writer from season 12 to season 19, and had also served as a guest star for the show.
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Kathy Griffin
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Played Sally Weaver in "The Doll" and "The Cartoon".
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Voiced Francine Rhenquist in "Bye, Bye, Nerdie".
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Jane Leeves
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Played Marla Penny.
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Voiced Edwina in "The Regina Monologues".
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Julia Louis-Dreyfus
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Played Elaine Benes.
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Voiced Gloria in the season 13 episode "A Hunka Hunka Burns in Love", the season 19 episode "I Don't Wanna Know Why the Caged Bird Sings", and the season 20 episode "Sex, Pies and Idiot Scrapes".
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Bette Midler
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Played herself in "The Understudy".
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Voiced herself in "Krusty Gets Kancelled".
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Megan Mullally
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Played Betsy in "The Implant".
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Voiced Sarah Wiggum in "Uncut Femmes".
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Bob Odenkirk
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Played Ben in "The Abstinence".
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Voiced the mob lawyer in "The Fat Blue Line".
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Regis Philbin
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Played himself in "The Opposite".
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Voiced himself in "Treehouse of Horror IX".
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Brian Posehn
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Played Artie in "The Burning".
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Voiced Dumlee in "A Father's Watch".
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Stephen Root
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Played Mr. Lager in "The Invitations".
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Voiced Bildorf in the season 32 episode "Wad Goals".
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Sarah Silverman
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Played Emily in "The Money".
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Voiced Nikki McKenna in "Stealing First Base" and "Moonshine River", herself in "Clown in the Dumps" and Rachel Cohen in "Treehouse of Horror XXVII".
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Marisa Tomei
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Played herself in "The Cadillac, Part 2".
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Voiced Sara Sloane in the season 14 episode "A Star Is Born Again".
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Robert Wagner
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Played Dr. Abbott in "The Yada Yada".
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Voiced himself in "Goo Goo Gai Pan".
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Patrick Warburton
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Played David Puddy in several episodes over the course of several seasons.
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Voiced Joe Swanson in "The Simpsons Guy".
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