When Homer Simpson was selling it all the animals ate it and became addicted to it. Everyone hates the Tomacco but can't keep themselves from eating the bad-tasting fruit because of the nicotine in it from the tobacco is extremely addictive. It looks like a tomato on the outside but inside it is the brown, flaky tobacco.
In "The Simpsons: Hit & Run", a billboard can be seen over a Tomacco field. In The Simpsons: Tapped Out, Tomacco is one of the crops that a player can grow on Cletus' Farm. In the game, it takes 60 minutes to grow, costs $15 and once harvested, the player gets 75 and 20 as a reward.