Closed captioning reveals that "Dancing Queen" by ABBA was supposed to be played instead.
When all the truckers tried to ram Homer and Bart off the road, Homer says to Bart that "they're hazing us to join the trucker fraternity, thank you sir may I have another." The "thank you sir may I have another" part is from Animal House.
When Homer faces off against Red the trucker at the steakhouse, Red sinks his hand down his pants like Al Bundy normally did on Married... with Children.
The decal on the side of Red's truck reads Red Rascal, and has a wolf and a sexy redheaded pin-up girl on the side, a possible reference to the 1942 Tex Avery cartoon Red Hot Riding Hood.
The Big Texan Steak Ranch in Amarillo, Texas is famously known for its promotion offering a free meal to anyone that can eat its 72 oz (4.5 lb, 2.04 kg) steak dinner in one hour.
The truck's built-in device said, "I'm afraid I can't let you do this, Red.", spoofing the line spoken by HAL in the 1968 film 2001: A Space Odyssey.
The woman on the "Wish You Were Her" postcard is Bettie Page.
In the Latin-American dubbing version, after Bart asks Homer if he can go with him, Bart says "go ahead, Lola!". This reference is to the 80's movie smash-hit (in all of Latin America and the Latino community in the US) of Lola la trailera.
When Marge opens the doorbell in an attempt to stop it from ringing, the internal wiring matches the bomb from the 1964 James Bond film Goldfinger_(film).
The original title for the episode was "Homer the Trucker".
Lisa Simpson's voice actress Yeardley Smith had a minor role in Maximum Overdrive as the bride of a newlywed couple who are trapped in the truck stop along with the other characters.
In one shot where Homer is talking to Marge, the back of the truck's cab is colored gray instead of its correct red.
When one of the truckers jumped to Homer's trailer to puncture his tires with a knife, he jumped from a pink truck that was behind the trailer, but when he looks back, his truck is gone.
In one shot when Marge is telling Homer not to fill up on bread during the eating contest, Homer's beard is yellow.