Marge takes Maggie to the Center for Pre-Emptive Education for the first day of pre-school. When she learns she can't stay with her, she checks her favorite mummy blog, and tries going to the gym, creating stuff with ceramics, and then goes to the Nuclear Plant to sex-prise Homer at his work place, but all go bad for different reasons.
Marge arrives at Well + Good, where they're hiring new people, and she made a good impression with them. The day of the opening, she's nervous but makes a good sale, before finding out they sell pot, making her a drug dealer.
The owner, Drederick Tatum, tries to convince her to stay, but she walks away from the job. Once brought the news home, they convince her to accept the job, helping people including Agnes.
When Otto tries to buy some, they keep trying to sell him all kind of products made of the drug, but Otto gets all confused by it and goes to Moe's. There he expresses his feelings toward the situation, and wanting to bring back the old way drug deals were made, Homer, Moe and Lenny recreate it in the tavern.
Meanwhile, Tatum presents The Drederick to the workers, a cannabis resort and spa, and wants Marge to present it, but denies it on the fact Homer is selling weed himself. The only way for her to keep working there is to stop Homer, and he refuses.
Tatum offers her an alternate way to do it, telling on him to the County Health Department. If he offers his customers food too, he'd be shut down. Marge goes through with the plan and the department closes the activity, betraying Homer.
At The Dredericks' opening ceremony, Homer gets in with a trick and upsets the influencers, revealing she's never tried pot. To save her face she tries some and feel the effect of getting high, understanding the truth behind it.
When Homer tries to light a joint, he lights up an electronic cigarette, which explodes causing a chain reaction that destroys the resort completely. In the end Quimby declares the cannabis outlaw, while Homer gets addicted to the cheese balls that stopped his newfound job.