In the comic book Ned tries to give Bart, Milhouse, and Nelson, Lil' Jesus, Jesus has a hairstyle similar to that of Lulu from the famous Little Lulu comic strip. The font from Lil' Jesus is also similar.
Homer writes on the sidewalk, "74 Oakland A's-Best Team Ever". He is referring to the Oakland Athletics, which won the 1974 World Series. Several members of the team drive by and thank Homer for remembering them. Sal Bando and Gene Tenace, two members of the actual team, make cameo appearances.
Homer lists Entertainment Weekly magazine among the bad things he was brought in the mail.
Part of the famous Jewish folk song "Hava Nagila" is heard during their wedding by the Missouri River.
Marge and Homer attend the wedding uninvited in a similar way to various scenes in the 2005 American romantic comedy Wedding Crashers.
The Springfield Keys are a parody of the Florida Keys.
One of the cleaning products Marge used was Mop 'N' Brag, a spoof of the product Mop & Shine.
The slow-motion scene where Marge falls and hits her head with a stool parodies the scene from Million Dollar Baby where Maggie (Hilary Swank) lands hard on her corner stool, breaking her neck.
Marge falls and hits her head with a stool, parodying the iconic scene from the 2004 American sports drama Million Dollar Baby where Maggie Fitzgerald (Hilary Swank) lands hard on her corner stool, breaking her neck and leaving her a ventilator-dependent quadriplegic.
Marge's quote, "Et tu Zud?" is a reference to Et tu, Brute?, a Latin phrase literally meaning "and you, Brutus?" which appears in Act 3, Scene 1 of William Shakespeare's play Julius Caesar.
One of the men in the speed date gathering says that he does not drive a Lexus, does not own a Learjet, and that he does not have a big beach house in La-La Land, a nickname for Los Angeles.
During the credits, Homer claims that Danny Elfman is only there because he's friends with Richard Sakai.
It is revealed that Milhouse is, or was, lactose intolerant. This has also been mentioned in the flashback episode "Lisa's Sax", wherein Milhouse says that the normal kind of milk could kill him.
Homer shows Marge a picture of him punching former president George Bush, a reference to the seventh season episode "Two Bad Neighbors", and then shows a picture of him punching current president George W. Bush. This is the first appearance of George W. Bush, and now every living president has made an appearance on the show. The most recent president who has not been shown in animated form is Herbert Hoover.
The opening gag, "I will not leak the plot of the movie", is a reference to the upcoming Simpsons movie.
Bart's scheme of painting house numbers on curbs to make money is possibly based on the real childhood of longtime Simpsons writer George Meyer.
When Dr. Hibbert is holding up the fingers, the nails are facing away from Marge, but in the next scene the nails are facing towards her.
When Marge is having her first speed date and says "Oh, that's so sad!", a person can be seen behind her, but then she reaches behind her for the air horn.
