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One Flu Over Springfield is a The Simpsons Winter Wingding story that appears in The Simpsons Winter Wingding #5.

In an introductory frame, Dr. Hibbert describes the story as an example of "how a little carelessness leads to a lot of misery". The story begins in the Kwik-E-Mart, where an obviously ill man approaches the counter to buy some flu medication. Apu, seeing the man sneezing on his wallet and on the box of medication, refuses to accept his "disease-tinged currency", leaving him at a loss for how to pay. Just then, Snake bursts into the store, steals the man's wallet and the medication he was going to buy, and runs off.

When Snake gets to his car, he takes a deep sniff of the man's wallet, exulting in "the sweet smell of illegally gotten gains". He hears the siren of an approaching Springfield Police car, jumps into his own car, and drives off at high speed. Very soon, however, Snake feels ill and sneezes on the steering wheel, coating it with phlegm. He then loses control of his car and crashes into a snowbank. Uninjured, Snake gets out of the car and flees on foot.