Antibooze
Antibooze is a drug that makes it so the person injected with it can never drink alcohol again.
History
After Moe blabbed secrets that other bartenders had told him at The Confidential, Artemis decided that Moe's regulars should be "cut off", which meant they would be injected with Antibooze. Barney was the first one to be injected since he was alone at his apartment. Moe then fled with Lenny, Carl and Homer as they were chased by other bartenders in town. Eventually, Lenny and Carl were both injected with Antibooze.
Homer and Moe eventually made it to Homer's house, where Dr. Hibbert was waiting for them. Dr. Hibbert told Homer and Moe that he made it through medical school by bar tending, then injected Homer with Antibooze before he left.
Three months later, Homer, Lenny, Carl, and Barney met up again. They decided to go and see Moe and decided to be his customers again. When Artemis saw the loyalty that they showed Moe, he decided to give them the antidote to Antibooze. Lenny, Carl, and Barney quickly took it, but Homer refused, preferring to be sober. Artemis then ordered every bartender in town to re-booze Homer.