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Tomacco, also spelt ToMacco, is a crop made by Homer. He created it when mixing tobacco and tomato seeds and using plutonium on the field to make them grow faster.

After leaving town due to a Southern colonel wanting to duel Homer, the Simpson family went to the Old Simpson Farm where Homer grew up. Homer decided to start the farm up again and live there for a while until the colonel left their house. After buying seeds of multiple crops, including tomatoes, tobacco, and gummy bears, Homer planted them and waited for them to grow. However, nothing grew on their farm, despite other nearby farms not having problems. Homer then placed a call to Lenny at the Nuclear Power Plant, who then mailed Homer some plutonium.

When Homer received the plutonium, he exposed the farm to it, causing it to glow a radioactive green. The family then went to sleep that night and woke up expecting to see huge crops on the farm. Homer was disappointed to find that there weren't any crops still and thought he was a failure. Lisa then noticed a sprout was growing, which excited Homer. Eventually the crops grew into what the family thought were ordinary tomatoes. However, when Bart took a bite out of one, he found that it tasted awful. Marge looked at the crop and realized that it was brown inside and Lisa worked out that it crossbred with the tobacco seeds. Despite hating the taste, Bart became addicted to the Tomacco and kept eating it...