Vicodude is a medicine that increases testosterone.
Dr. Hibbert tried to prescribe Vicodude to Homer because he had low testosterone. However, when Dr. Hibbert tried to show a video about Vicodude to Homer, an advert for the Road Monster XXXL 550 played before the video. Homer decided to buy the truck instead of take the medicine.
Behind the Laughter
The name of Vicodude is a reference to the drug Vicodin.