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The Itchy & Scratchy Show is an animated TV show and a segment of The Krusty the Klown Show on Channel 6.

The show involves a anthropomorphic mouse named Itchy and a anthropomorphic cat named Scratchy attempting to kill each other, though Itchy kills Scratchy in every cartoon except for one episode. The show contains a huge amount of blood and gore and cartoon violence. It is a parody of Tom & Jerry, but exaggerated to be more violent and gory, unlike Tom & Jerry which only had slapstick humor. There are at least 1,328 episodes of the show.

Most of the time, each Itchy & Scratchy episode is based on some kind of theme that The Simpsons episode is being aired as. For example, The Itchy & Scratchy episode "diePod Slaylist", shows Scratchy listening to a MyPod when Itchy turns the volume to extreme levels to make Scratchy's eye's explode, this is related with Lisa owning a MyPod.

Chester J. Lampwick invented Itchy in the year 1919 and owns the rights to Itchy. Lampwick was also known as the "father of cartoon violence." Roger Meyers, Sr. (1890–1985) plagiarized Itchy and established Itchy and Scratchy Studios in 1921. Originally Itchy was called "Itchy the Lucky Mouse" (a parody of Oswald the Lucky Rabbit). He starred in his first cartoon made by Lampwick, "Manhattan Madness".

Scratchy starred in his first cartoon in 1928, entitled That Happy Cat. The film, which is about fourteen seconds of animation showing the cat whistling and tipping his hat, did very poorly. It is unknown who created Scratchy, or if he was plagiarized by Meyers Sr. in the same way that Itchy was.

Later in 1928, Itchy and Scratchy starred in their first cartoon together entitled "Steamboat Itchy" a parody of Disney's Steamboat Willie featuring Mickey Mouse.