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Granddaddy-O! is a Simpsons Comics story that appears in Simpsons Comics #204.

Homer and Bart are pulling a prank on Flanders, but they are caught and yelled at by Nedsel. Ned tries to calm his father down, but then he starts complaining about his son, so Nedsel and Agnes decide to go home but Marge stops them and lets them stay with them for a few days. Nedsel and Agnes soon become interested in Lisa and her saxophone, and they start jamming together, making Marge feeling bad for herself. Homer and Nedsel become friends after Homer finds out that Nedsel knew Mona. Agnes goes to see a movie with Rod and Todd but the movie scares them, so they go to the park instead. Marge tries to act like Agnes for Lisa, but she just thinks she is behaving strangely.