Template:Season 21 Guest Stars
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Guest stars in season 21
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| Seth Rogen • Kevin Michael Richardson • Matt Groening • Chuck Liddell • Jonah Hill • Neve Campbell • Smothers Brothers (Dick Smothers • Tom Smothers) • Peyton Manning • Eli Manning • Cooper Manning • Kim Cattrall • Huell Howser • Jordan Nagai • Mitch Albom • Anne Hathaway • Gary Larson • Eartha Kitt • Jackie Mason • Chris Martin • Bob Costas • Wren T. Brown • Sarah Silverman • Angela Bassett • Sacha Baron Cohen • Yael Naim • Joe Mantegna • Jane Kaczmarek • Maurice LaMarche • Eddie Izzard • Don Pardo • Kelsey Grammer • Ryan Seacrest • Randy Jackson • Ellen DeGeneres • Kara DioGuardi • Simon Cowell • Rupert Murdoch |