Wikisimpsons - The Simpsons Wiki
Estes Kefauver was an American politician who headed a much-publicized investigation into organized crime.
After his family failed to show up for an important event, Grampa told them that he felt "as lonely as Estes Kefauver at a meeting of Murder, Inc.". When they all gave him blank stares he retorted "that actually makes sense! Look it up!"