Lindsey is known to be a common youth-hater. Lindsey, outraged at paying high damages for a particular riot that the youth have caused, formed an anti-youth group named SSCCATAGAPP (Singles, Seniors, Childless Couples And Teens And Gays Against Parasitic Parents), and lobbied to deprive Springfield of all child-friendly things. Her campaign nearly succeeded, but was thwarted at the last moment when Bart, Lisa, and the other kids in Springfield hugged all the adults, infecting them with "kid germs". The adults collapsed with sickness and weren't able to vote, causing the campaign to fail.
An alcoholic (she says so matter-of-factly to Homer when she appears in Moe's Tavern), it is later revealed that she is the head of the Alcoholics Anonymous branch in Springfield. At meetings she says "So we all know why we're here - to be sober .. and to network!"
She is often seen as a member of the Springfield Republican Party. However, she was once seen attending a Democratic Party meeting.
Lindsey tends to flatly admit things that others would be embarrassed to admit. She acknowledged being a registered sexual predator and that she cannot cry due to a botched face lift.
She is the host of the R.O.C.C., the Remote Onsite Correctional Center, a new detention center for Springfield Elementary School.
Lindsey has popped up in several capacities, seemingly working at a different job every time she appears. Job titles have included the aforementioned network executive, as well as marketing researcher, financial planner (making a point that she wasn't a financial consultant), public relations consultant, venture capitalist, advertising executive, cell phone company exec. and executive with the Child Development Group. After she introduces herself (again) to Homer and Marge, Marge says, "We've met you many times, Ms. Naegle; why do you keep changing jobs?" To which she flatly replies, "I'm a sexual predator". She later becomes a replacement for Smithers when he quits the Power Plant.
Naegle once dated Ned Flanders, but the date was interrupted by Naegle receiving a fax (from a fax machine strapped to her leg) which indicated she had been indicted. She is an enthusiastic practitioner of the childfree lifestyle, and at one point spearheads a movement to make Springfield less child-friendly. Once romantically linked with Judge Roy Snyder, she is a graduate from the Wharton Business School. She is a stereotypical upper management executive, and her ventures almost always promote the business buzzword "synergy". Marge told Homer that if she died, he would be allowed to remarry to Naegle, as seen on a list in the back of his closet.
It is implied that she's been sleeping with Krusty the Clown, as both were giggling and blushing. She has also been seen with Moe Szyslak, Sea Captain, Disco Stu, Blue-haired lawyer, Rainier Wolfcastle, Lenny, and Kent Brockman.