Abbey with her half-brother Homer.
Abbey was the result of a brief relationship between Edwina and Abe during the Second World War. Abe was in England before D-Day and had one night of passion with Edwina before he had to leave England. Unknown to Abe, Edwina became pregnant and the result was Abbey.
Abe and the rest of the Simpson family first met Abbey when she was in her 50s. They had been visiting England and were on their way to catch their plane back to America, and Edwina and Abbey approached them in the airport. When Abe realized that Abbey was his daughter, he ran off to the plane screaming, after saying "See you in Heaven." Homer, however, took an instant liking to Abbey.
While Abbey is obviously a biological Simpson (aside from her appearance and personality, she was born less than a year after Grampa's affair with her mother) she is not officially recognized by the family and never explicitly called a Simpson.
It is possible that even though she is female, Abbey may have somehow inherited the Simpson Gene defect that most of the Simpson males have. As Dr. Simpson pointed out, all the Simpson women have high intellects and good careers, because the defective gene is on the Y chromosome. This could be an instance of the gene skipping a generation or striking some and missing others, as her half-brother Herbert Powell also supposedly inherited the Simpson Gene, but it has not significantly affected him.