When Homer Simpson was selling it all the animals ate it and became addicted to it. Everyone hates the Tomacco but keeps eating it because of the nicotine in it from the tobacco. It looks like a tomato on the outside but inside it is the brown, flaky tobacco.
In "The Simpsons: Hit & Run", a billboard can be seen over a Tomacco field. In The Simpsons: Tapped Out, Tomacco is one of the crops that a player can grow on Cletus' Farm. In the game, it takes 60 minutes to grow, costs $15 and once harvested, the player gets 75 and 20 as a reward.