Osaka Flu

The Osaka Flu is a illness that took over the city of Springfield in the episode Marge in Chains.

History
A factory worker on a assembly line in Japan, which was assembling the "Juice Loosener", a juicer sold on a shopping show and invented by Dr. Nick, coughs into the box that was headed to Homer, filling it with airborn germs. When the juicer arrives at Sprignfield, the Simpson family and the rest of the town get the Osaka Flu.

Marge, stressed by the fact that she has to take care of everyone, ends up shoplifting a bottle of Bourbon from the Kwik-E-Mart. Lionel Hutz defends Marge at the trial but loses the case and she's sentenced to the Springfield Women's Prison. In her absense, Homer struggles to cope with the family without her and the family is in a dreadful state. Without her guidance at the bake sale, the town went to a riot due to the fact that they didn't raise enough money for a statue of Abraham Lincoln, and buying one of Jimmy Carter. Mayor Quimby intervenes releasing her from jail and revealing the statue being president Carter's with Marge's hair on top of it.

The Simpsons: Tapped Out
When Major Quimby fills the town with tourists, opening a recreation of France, Japan and Brazil, they bring the flu in town, spreading it all over other tourists and all over the world. Dr. Hibbert creates a vaccine, but the consequences of it are still unknown.