Aliens

Aliens is a sci-fi/action movie and the second in the Alien franchise.

History
Near the middle of the movie, the Colonial Marines' dropship crashes and Private William Hudson laments, "That's it, man! Game over, man! Game over!" The quote is mentioned in Comic Book Guy's list of the "Greatest Quotes of All Time".

Comic Book Guy also recommends using the "Game over, man!" quote when you lose at a video game.

Behind the Laughter
Various aspects of the movie, as well as the series as a whole, have been parodied in a number of television episodes and other Simpsons media.