Repressitol

Repressitol is a memory-suppressing medication. Milhouse has a prescription for it.

History
On Francine Rhenquist's first day at Springfield Elementary School, during recess she sat by herself on the seesaw because no one would talk to her. Up on the jungle gym, Bart and Milhouse were making unkind comments about Francine. Lisa, overhearing, said to Milhouse, "Give her a break. Remember your first day at school?" Milhouse replied, "Not as long as I keep taking these!" and held up his bottle of Repressitol.

Behind the Laughter

 * The medication's name is a wordplay on "repress it all", referring to its memory-suppressing effects.