Prozac

Prozac is a brand name of antidepressants.

History
Homer made a homemade Prozac with ice cream.

Homer and Marge are watching on the TV to Ruth Bader Ginsburg strangling a security guard. Marge takes out a bottle of Prozac from her hair, downing some pills, before seeing the bottle is empty, claiming it was supposed to last her for the whole 4 years.